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Strikingly, our model uncovers highly enriched and differential zones of mitophagy in the developing heart and within specific cells of the adult kidney.

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In contrast to earlier theories, we do not assume that the cell in which sex arose had already evolved a mitotic cell cycle. The genetic interactions between mitochondria and the nucleus have come under intense interest of late, not only because they are important for modern biology but also because they were likely important very early in eukaryote evolution, also at the origin of sex Lane, ; Havird et al.

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